Role of interleukin-18 in host defense against disseminated Candida albicans infection.
نویسندگان
چکیده
In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.
منابع مشابه
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عنوان ژورنال:
- Infection and immunity
دوره 70 6 شماره
صفحات -
تاریخ انتشار 2002